基于网络药理学与分子对接技术探讨瓜萎白半夏汤降血脂的作用机制及潜在药效成分

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AbstractObjective：ThepotentialpharmacodynamiccomponentsmechanismGualou Xiebai Banxia Decoction（GXB）inlipid loweringeffctswereexploredbasedonnetworkpharmacologymoleculardockingMethods：ThechemicalcomponentsGXBwere screenedthroughthe radionalmedicinesystempharmacologydatabase（TCMSP）databaseiterature.Componenttargets wereobtainedusing thePharmMapperdatabase.TherelevantdiseasetargetshyperlipidemiawereobtainedbytheHumanMendelian Genetics Database（OMM），theHumanGeneDatabase（GeneCards）.Theintersectioncomponenttargetsdiseasetargetswas takentoobtainpotentialtherapeutictargets.Networkprotein-proteininteractions（PPl）wasconstructedthroughtheSTINGdatabase thecoretargetswerescreenedout.Thepotentialtherapeutictargetsweresubjectedtogeneontology（GO）functionalanalysis KyotoEncyclopediaGenesGenomes（KEGG）sinalingpathwayerichmentanalysisusingCytoscapestware，nda"tradional mediciomponenttarget-pataynetworkwasostructedTesoerytudiooareasusedolecularoinga conductedbetweentheactiveingredientsthecoretargettoscreenforpotentialeficacycomponents.Results：Thenetwork pharacologymethodidentfied65chemicalcomponents，6potentialtherapetictargets31coretargtsiGXB.TeGOfunction analysisyielded253entrisKGGenrichmentanalysisyielded3signaingpathwasleculardockingidentifid3potetactive ingredients.estudyverfidtatthepoteialactiveingredientsinGXBshowedstrongbindingactityithtecoretargetCousio： GXBmayexertitseffctsthroughpotentialpharmacologicalcomponentssuchasqueretinapigeninlycorin，eugenolocore targetssuch as serum albumin（ALB），retinoic acid receptor RXR- α （RXRA），peroxisomeproliferator-activatedreceptorα（PPAPA）， regulatigsignalingpathwayssuchasperoxisomeproliferatoractivatedreceptor（PPAR），hypoxiaiduciblefactor（HF-1）， phenylalaninemetabolisifuecinliidstesiseakdobsotiotebpromotinglidetabolisfatycidbndig transportion， exerting its lipid-lowering effect.

wordslipidlowering;GualouXiebaiBanxia Decoction；mechanism；pharmacodynamiccomponents；network pharmacology; molecular docking

近年来，人们患高脂血症的风险不断增加，其可引发冠心病、心肌梗死、糖尿病等诸多疾病，能加速心血管动脉粥样硬化过程，是引起心血管疾病的主要危险因素，其危害大，涉及广，且患病人群趋于年轻化，已成为棘手的公共健康问题。（剩余9711字）