基于网络药理学和分子对接技术探讨人参-茯苓药对治疗阿尔茨海默病的相关机制

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doi：10.12102/j.issn.1672-1349.2025.14.005

TheMechanismof Ginseng-Poria Medicinal CombinationforTreatingAlzheimersDisease BasedonNetworkPharmacologyand Molecular Docking Technology

ZHOUMengling1，WANG Yanli'，YUBoru²

1.BejingHspiaofdeiaiaicaitjnasci UniversityofTraditionalChineseMedicine，Tianjin3ooo73，China

Corresponding Author YU Borui，E-mail：yu_borui@ 163.com

AbstractObjective：ToexplorethemechanismsofGinseng-PoriamedicinalcombinationforthetreatmentofAlzheimersdisease（AD） Basedonetworkpharmacologyandmoleculardockingtechnology.Methods：TheactivecomponentsofGinseng-Poriamedicinal combinationwerepredictedandscreenedundertheconditionsoforalbioavalabilty（OB）anddrug-ikenessDL）usingtheTradional ChineseMedicineSystemPharmacologyTechnologyPlatform（TCMSP）TheactiontargetsrelatedtothetreatmentofADwerecolected throughtheGeneCardsdatabase.Thecomponent-targetandtarget-proteininteractionnetworkdiagramswereconstructedusingthe DAVIDdatabaseandCytoscape3.8.2software.Thetarget geneswereanalyzedforgeneontology（GO）functional enrichmentanalysis andKyotoEncyclopediaofGenesandGenomes（KEGG）pathwayenrichmentanalysis，andthecorecomponentsandcoretargetsinthe pharmacologicalnetworkweresubjectedtomoleculardocking.Results：TheactivecomponentsinGinseng-Poriamedicinal combinationwere analyzed using the TCMSP database，mainly including kaempferol， β -sitosterol，andstigmasterol.Itactedon76 targets related to AD，including tumor necrosis factor（TNF），peroxisome proliferative activity receptor γ（PPARG） ，interleukin-1 β（IL-1β）， nitric oxide synthase3（N3）ndUrotoogeneJ），tough9teuroactiveligandreceptorinteractioathayaciiaing pathwayolingicsasendopamiegicaps.Itartiipatedin5icalpocsssidingoliegictic energytrasssrupscetyliadepsditolplatioetinti efect.Theresultsofmoleculardockingshowedthatthemainactiveingredientsscreenedwithbeterbindingactityandtheportant targets.Conclusion：Ginseng-PoriamedicinalcombinationfortreatingADshowedthecharactersticsofultiplecomponentstple pathways，and multiple targets.

KeywordsAlzheimersdisease;Ginseng-Poriamedicinalcombination;networkpharmacology;moleculardocking;mechanism

阿尔茨海默病（Alzheimersdisease，AD）属于老年期痴呆的主要类型[1]，临床以多认知领域功能进行性下降，伴发多种精神行为症状为主要临床表现，是老年人致残的主要疾病之一[2]。（剩余12522字）