桔梗汤化学成分、药理作用机制及临床应用的研究进展
中图分类号R965；R284 文献标志码A 文章编号 1001-0408（2025）18-2348-05
DOI10.6039/j.issn.1001-0408.2025.18.23
Research progress on the chemical constituents，pharmacological mechanisms and clinical application of Jiegeng decoction
HUANG Yun1，2，HUANG Shunwang^， QIAO Jinwei12，XU Qian1²，GAO Xiaoming²，BAO Xuemei¹， YANG Manqin'，XIE Ruonan12，CAI Ming²（1.Dept.of Pharmacy，the Second Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230o61，China;2. Xie Ruonan Anhui Province Famous Chinese Pharmacist Studio， Hefei 230061，China;3.Hefei Innovation Medical Technology Co.，Ltd.，Hefei 230088，China）
ABSTRACTJiegengdecoctionisaclassic prescriptioncomposedof two Chinesemedicinal herbs：Platycodon grandiflorumand Glycyrrhizauralensis.Ithas theeficacyofdifusing lungqi，resolving phlegm，relievingsore throatanddischarging pus，andis commonlyusedinthetreatmentofrespiratorydiseasessuchascoughandpharyngodynia.Thisarticlereviewsthechemical components，pharmacologicalmechanismsandclinicalaplicationsofJiegengdecoction.ItwasfoundthatJiegengdecoction containstriterpenoidsaponins，flavonoids，glycosides，acids，andothercomponents，withplatycodinD，platycodin D2 glycyrhizicacid，glcyhetinicacid，quiritin，tc.，servingasthemainactivepharmaceuticalingredients.Jiegengdecotionand itschemical constituentsexertanti-inflammatoryeffects by inhibiting signaling pathways such as nuclearfactor- κB and mitogenactivatedproteinkinases，anddemonstrateanti-tumoractivitiesthroughmechanismslikemodulatingthetumorimmune microenvironmentandpromotingcancercellapoptosis.Additionally，itexhibitsvariouspharmacologicalactionsincluding antibacterial，ntiviralandantioxidanteects.Clnicallyiegengdecocionitsodidpresciptiodcompondatio arewidelyused inthetreatmentofrespiratory diseasessuch ascough，pneumonia，and pharyngitis，aswellas digestivesystem disorders like constipation.
KEYWORDS Jiegeng decoction；chemical constituents； pharmacological effects； clinical application
桔梗汤最早记载于东汉时期《伤寒杂病论》，收录于国家中医药管理局和国家药品监督管理局发布的《古代经典名方目录（第二批）》，是治疗咽痛、咳嗽的经典名方[，其临床价值与传承意义重大。（剩余10514字）
