中药调控NLRP3炎症小体干预肾纤维化的作用机制研究进展

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中图分类号 R931.6;R256.5；R285 文献标志码A 文章编号1001-0408（2025）18-2334-07

DOI 10.6039/j.issn.1001-0408.2025.18.21

Research progress on the mechanisms of traditional Chinese medicine regulating NLRP3 inflammasome to interveneinrenalfibrosis

HUANG Chenjie，YUAN Wenqi，LU Yaohong，YAN Ziyou（Clinical Medical College，Jiangxi University ol Chinese Medicine，Nanchang 330004，China）

ABSTRACTRenalfibrosis（RF），characterizedbyglomerulosclerosisandtubulointersitialfibrosis，isacentralpathological process inchronic kidneydisease（CKD）.The nucleotide-binding domain leucine-richrepeatand pyrindomain-containingreptor 3（NLRP3）inflammasomeiscloselylinkedtotheoccurrenceandprogressionofRF.Thisreviewsystematicallyelucidates the mechanismsoftheNLRP3 inflammasome inRF，andsummarizes thecurrentresearchontheinhibitionofNLRP3 inflammasome activationbysingleChineseherbs，activecomponentsof traditional Chinesemedicine，Chineseherbalcompounds，andChinese patentmedicinesforthepreventionandtreatmentofRF.Theexistingstudieshavedemonstratedthat singleChineseherbs （Campanumoealancifolia，Dioscoreazingiberensis），activecomponentsof traditional Chinesemedicine（moroniside， liquiritigenin，rosmarinicacid，magnoflorine，fucoidan，etc.），Chineseherbalcompounds（Bushen huoxue formula，Tongluo yishendecoction，Shizhi formula，Bixie fenqingdrink），and Chinesepatentmedicine（Suyin jiedu granule）caninhibitthe activationoftheNLRP3inflammasome tocounteract inflammatorydamage.Thisafectsmultiplepathways （NLRP3/caspase-1/ gasderminD，NLRP3/interleukin-1β/Smad，etc.）andrelatedupstreamanddownstreamtargetsofitsactivation，effectively reducingpyroptosis，mitigatingoxidativestress，promotingmitochondrialautophagy，nhibitingfibroblastactivation，andreducing excessive extracellular matrix deposition，thereby exerting anti-RF effects.

KEYWORDSNLRP3 inflammasome；renal fibrosis；traditional Chinese medicine；mechanism；chronic kidneydisease

慢性肾脏病（chronickidneydisease，CKD）常隐匿起病、持续进展，若缺乏有效干预，将发展为终末期肾病，造成巨大的健康及经济负担。（剩余19181字）