基于四气理论的中药单体对化疗致骨髓抑制的作用机制研究进展

中图分类号R931.6 文献标志码A 文章编号 1001-0408（2025）18-2341-07

DOI 10.6039/j.issn.1001-0408.2025.18.22

Research progress on the mechanism of traditional Chinese medicine monomersactingon myelosuppression afterchemotherapybased on the fourproperties theory

ZHANG Sihan1，2，WANG Tingting³，ZHAO Zhifen4，KANG Hanyu12，JI Jiaqi2，GUO Ziqiang1，2，LIU Tongl.2， JIANG Shiqingl（1.Dept.of Hematologyand Oncology，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;2.First Clinical Medical Colege，Henan Universityof Chinese Medicine， Zhengzhou 450046，China;3.Dept. of Emergency，the First Afiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China; 4.Pediatric Hospital，the First Afiliated Hospital of Henan University ofChinese Medicine，Zhengzhou 45oo03，China）

ABSTRACTChemotherapyisanimportant treatment fortumors，butmost patients experience varyingdegresofchemotherapyinducedmyelosuppression.Fourpropertiestheoryof traditional Chinese medicine（TCM）hasuniqueadvantages inimproving chemotherapy-inducedmyelosuppression.Themonomers fromTCMwithdiferentpropertiesandflavors，suchascold-natured（e.g. Scutellria baicalensis，Rhuschinensis），cool-natured（e.g.Ligustrumlucidum，Ophopogonjaponicus），warm-natured（e.g. Panaxginseng，Epimediumbrevicou，Curcumalonga，Angelicasinesis），ot-natured（e.g.Cinamomumcaia，Acoitm carmichaeli），andneutral-natured（e.g.donkey-hidegelatin，Lyciumbarbarum，Rhodiolarosea，fungi），canexertantimyelosuppressveefectsbyreducingdamage tohematopoieticstem/progenitorcels，improvingthe bonemarrowhematopoietic microenvironment，inhibitingtheoxidativestressresponse，egulating signaling pathways，soas toultimatelyrepaire inflammatory damage and improve hematopoietic function，thereby playingan anti-myelosuppressive role.

KEYWORDStraditional Chinese medicine monomers；four properties theory；myelosuppresion；chemotherapy；mechanismof action

化疗致骨髓抑制（chemotherapy-inducedmyelosup-pression，CIM）是恶性肿瘤治疗中的核心并发症之一。（剩余19010字）