桑芪首乌方对高血压早期肾损害血管内皮功能影响的临床观察

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【中图分类号】R289.5 【文献标志码】A 【文章编号】1007-8517（2025）10-0115-04

DOI： 10.3969/j . issn.1007-8517. 2025.10. zgmzmjyyzz202510022

Clinical Observation of the Effect of Sangqi Shouwu Formula on Vascular Endothelial Function inEarlyRenal Damage ofHypertension

GUO Shiyu1WEI Danxia1 LI Dongyun1HU Zhiyu1*LI Huijuan² 1.KunmingHospital of Traditional ChineseMedicine，Kunming 65OO11，China; 2.Yunnan University of Traditional ChineseMedicine，Kunming 65O5OoO，China

Abstract：ObjectiveToinvestigatetheefectofSngqishouu Decoctiononvascularendothelialfunctioninearlystageofrenal damageinhypertension.Methods72patientswithearlyrenaldamageofhpertensionadmitedtotheDepartmentofNephologyand Rheumatism weredivided intotwogroupsaccording torandomnumbertablemethod，36cases ineach group.Thecontrolgroupwas treatedwithirbesartantabletandthetreatmentgroupwastreatedwithSangqishouuprescriptiononthebasisofIrbesartantablet. The course of treatment was 4 weeks. The serum levels of endothelin -1 （ET-1）and nitric oxide （NO） in the two groups were compared，andteotalectiveatefetwogrousasulatedResultsftertreament，televelofETinthtreantgoup was lower than that in the control group （ P<0.05 ），the level of NO and the total eective rate were higher than that in the control group （ P<0.05 ）.Conclusion Sangqi shouwu formula can improve vascular endothelial function in patients with early renal damage of hypertension，and the effect is outstanding.

Key words：Sangqi shouuu Decoction；Early Renal Damage in Hypertension；Vascular Endothelium；ET-1；NO

高血压是全球内重大公共卫生问题，长期以来大众对高血压治疗的认识存在误区，导致血压控制不理想、不达标，日久累及多个靶器官损害。（剩余5372字）