基于新安固本培元理论探析人参－黄芪治疗子宫切口憩室的作用机制

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【中图分类号】R271.9 【文献标志码】A 【文章编号】1007-8517（2025）10-0007-08

DOI：10.3969/j.issn.1007-8517.2025.10.zgmzmjyyzz202510002

Exploring the Mechanism of Action of Ginseng -Astragalus in the Treatment of Diverticulum ofUterineIncisionBased onthe TheoryofGuben Peiyuan

XU Yuke1CHEN Zhicong1GUO Jinchen1CHU Jijun²* 1.Anhui University of Chinese Medicine，Hefei 23OO12，China; 2.The First Afiliated Hospital of Anhui University of Chinese Medicine，Hefei 23oo31，China

Abstract：ObjectiveToanalyzethepotential mechanismof panax-Astragalus intreatingdiverticulumof uterineincisionbased on Guben-Peiyuantheoryand network pharmacology.Methods TCMSPand UnitProtdatabases wereused todeterminetheactiveingredients，targetsandcorespondinggenenames of ginsengandastragalus.Disease targetswerescreenedfrom GeneCardsandMIM databases.Cytoscape3.7.2softwareandSTRINGplatformdatabasewereused toconstructa“drug-activeingredient-keytarget" network，obtanproteininteractionnetwork，andperformvisualnalysis.DAVIdatabaseasusedtopeformGOfunctionalaalsis andKEGG pathwayenrichmentanalysis.Results Therewere34kindsofactiveingredients，249coresponding target genes，1702 diseasetargets，36 drug and disease intersection targets.Active ingredients such as kaempferol，ononcetin，quercetin， β -sitosterol，7-O-methyl-isobioprophyl mainlyactontargetssuchas TNF，IL1B，AKT1，CASP3，PTGS2，PPARG toafectoregulate IL-17，AGE-RAGE，TF，fluid shearstress，andarteries indiabeticcomplications Atherosclerosisandothersignaling pathways toachievethepurposeoftreatingdiverticulumofuterineincision.ConclusionThisstudypredictedthe mechanismofpanax-stragalusintreatingdiverticulumofuterineincisionobjectively，andprovidedscientificeferencevalueandpreliminaryfoundationforanal andclinical trialsin the future.

Keywords：DiverticulumofUterine Incision；GubenPeiyuan；Ginseng-Astragalus；Network PharmacologyMechanismof Action

子宫切口憩室作为剖宫产术后远期并发症的代表，主要症状有非经期异常出血、月经期经血淋漓不尽甚至崩漏等，本病在中医古籍没有记载，现多根据其症状表现纳入“异常子宫出血”“月经过多”“经期延长”“崩漏”等范畴[1-3]。（剩余11703字）