miRNA靶向Wnt/β-catenin信号通路调节骨肉瘤研究进展

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中图分类号：R738.1 文献标识码：A文章编号：1006-1959（2025）12-0171-09

DOI：0.3969/j.issn.006-959.05..037

Research Progress of miRNA Targeting Wnt/β-catenin Signaling Pathway to Regulate Osteosarcoma

JIANGDengchen'，WANGXingsheng²，XUSihong2，WANGXiaoqiang²，DANGZeliang²，PENGPei²，QIQisun （1.ClinicalCollgeofTaditioalineseMedicine，GansuUnversityofneseedicine，Lanzhouoo，Gansu，Cina; 2.Trauma Center，Gansu ProvinceHospital of TCM，Lanzhou 73Oo5O，Gansu，China）

Abstract：Osetodeie andtheunderlyinmoleularmecanismseainporlyuderstodOverthepastdcade，oughtesuvivalandprogosisofosteoso patientsveodtalateoietassisotasaesftleereis toidentifyoelosteosacoaomakestoevelosifaedterapidcsindestadingsteosacoasoleulasm haverevealedthatsregadsndteWnt/βateinsialinataoltiveliveoresioetastasisddug resistance.Moreover，miRNAs can modulate the Wnt/β -catenin pathway through multiple mechanisms to promote or inhibit osteosarcoma progression andalterdrugesistane.Somemslsofocompetitieedogeousnetwoks（ceNETs）ithiRAsndlRAs.Tiseveeploste roles of miRNAs targeting the Wnt/β- catenin pathway in osteosarcoma and their associated ceNETs，aiming to provide a theoretical foundation for future research.

KeyWords：Osteosarcoma; miRNA; Wnt/β -catenin;Signalingpathway

骨肉瘤（osteosarcoma，OS）是一种原发性骨骼恶性肿瘤，发病率呈双峰型，高峰期为18岁和60岁，男性稍多见，长骨的干端区域是骨骼中最活跃的部位，也是OS生长的主要部位，其中肉瘤细胞形成未成熟骨或类骨组织。（剩余23359字）