中药在骨质疏松治疗中的研究概况

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中图分类号：R274 文献标志码：A 文章编号：1007-2349（2025）12-0085-06

【Abstract】With the global aging of population，osteoporosis，as a common bone metabolic disease，has become a significant challenge in public health forits treatment.Traditional Chinese medicine has playedan important role in thetraditional treatment of osteoporosisdue to itsunique therapeutic concepts and abundant herb resources.It is very important to explore the application of Chinese herbs and their components in the treatment of osteoporosis，especially to analyze their potential mechanisms of action from the perspectives of modern pharmacologyand molecular biology. By reviewing relevant literature，the efects of Chinese herb components on key signaling pathways （such as Wntβ- catenin，Notch，MAPK，etc.）are summarized，as wellas how these pathways regulate bone metabolism and osteocyte activity.Inaddition，theadvantagesand limitationsofChinese herbsand conventional drugs inthetreatmentofosteoporosis were compared and the potential value of Chinese herbs in clinical application explored.Although Chinese herbsshowaprospect inthe treatment ofosteoporosis，therearestill challenges suchas standardizationof components and determination of dosage.Future research should be dedicated toaddressng these issues and exploring the mechanismof action of Chinese herbs in the treatment of osteoporosis，providing a new perspective for future research and clinical practice.

【Key words】 Osteoporosis；Modern treatment; Signal pathway;Bone metabolism

骨质疏松症（osteoporosis）是一种全身骨骼退行性疾病，以骨密度减少、骨微结构破坏、骨折风险增加为特征的慢性疾病[1]，尤其在围绝经期晚期和更年期早期雌激素水平急速下降患者中普遍存在2。（剩余8138字）