基于网络药理学与分子对接探究牵正散治疗周围性面瘫的分子机制

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中图分类号： R745.1+2 文献标志码：A 文章编号：1007-2349（2025）09-0049-06

Study on the Molecular Mechanism of Qianzheng Powder in the Treatment of Peripheral Facial Paralysis Based on Network Pharmacology and Molecular Docking

CHEN Fan-fan，XIAO Hong-bo

（1.Anhui University of Traditional Chinese Medicine，Hefei 23oo38，China; 2.TheFirst Affliated Hospital of Anhui University of Traditional Chinese Medicine，Hefei 23oo32，China）

【Abstract】Objective：To study themolecular biological mechanismof Qianzheng Powderinthe treatment of peripheral facialparalysis（PFP）basedon network pharmacologyand molecular docking.Methods：The active ingredientsand their action targetsof Qianzheng Powder were collected through the TCMSP，HERB databases and literature. The disease targets were obtained from the GeneCards and OMIM databases.The related proteins were obtained using the STRING platform data.The protein-protein interaction network was constructed withthe help of Cytoscape software.GO and KEGG enrichment analyses were conducted using the DAVID platform.The binding of active ingredients to target proteins was explored through molecular docking.Results：21 active ingredients and 5O2 target sites of Qianzheng Powder were screened out. A total of4，240 disease targets were screened out.The intersection yields 49 core targets.GO enrichment yielded 1135 entries，and KEGG enrichment yielded179 pathways.The molecular docking could stably bind to the selected targets.Conclusion：Qianzheng Powder inthe treatmentof PFPhas the characteristics of multiple targets and multiple pathways，and maybe associated with regulating signal pathways such as immune response，cellular stress，neural transmission and apoptosis.

【Key Words】Qianzheng Powder；Peripheral Facial Paralysis；Network Pharmacology；Molecular Docking

周围性面瘫（peripheral facial paralysis，PFP）是一种常见的非特异性、急性发作的单侧面神经功能障碍，其特征为一侧面部肌肉突然无力或完全瘫痪[1]。（剩余7373字）