生活方式干预对心血管代谢性共病病人影响的Meta分析

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Influence of lifestyle intervention on patients with cardiovascular multimorbidity：a Meta-analysis ZENG Jinghui'，SONG Kai'，LI Na1，ZHANG Jing1，YANG Longhui'，ZHU Ruifang1，2*

1.Schoolof Nursing，Shanxi Medical University，Shanxi O3ooo1China；2.FirstHospitalofShanxiMedicalUniversity *Corresponding Author ZHU Ruifang，E-mail： ruifang.zhu@ sxmu.edu.cn

AbstractObjective：Tosystematicallevaluatetheimpactoflifestyleinterventionsonvariousindicatorsofmetabolicsyndromein patientswithardiometabolicultimorbidityndtoprovideevdencebasedisightsfoiseasepreventionintispopulationetos： Randomizedcontroledtrials（RCTs）relatedtocardiometabolicultimorbidityandlifestyleinterventionswereretrievedfromdatabases includingCNKI，WanFangDatabase，VIP，PubMed，theCochrane Library，WebofScience，andEMbase.Thesearchperiodspaned fromJanuary4，tptebr2otalltearrsiepedentlyuctedliatureeigdtaecid riskofbiasassessment.Meta-analysiswasperformedusingRevMan5.4.1software.Results：Atotalof18articles wereincluded.It involved1596patients.Metaanalysisresultsdemonstratedthatlifestyleinterventionssignificantlyimprovedhig-densitylipoprotein choesterol （HDL-C）（WMD=0.10， 95% C10.00 ）-0.20，P=0.04） ，fasting blood glucose （FBG）（WM） （204号 P=0.001 ，triglycerides（TG）（WMD= -0.48 ， 95% CI -0.73--0.24 ），systolic blood pressure （SBP） （WMD ， 95% CI -12.06-3.39 ， P=0.000 5），and waist circumference （WC）） （WMD ， 95% CI -6.16--0.24 P=0.03 ）.Subgroup analysisevealedthatlifestyleinterventioslasting morethan3monthssignificantlyimproedHD-C，FBG，G，BP，andWleels inpatients with cardiometabolic multimorbidity，with statistically significant differences ΔP<0.05 ）.Conclusions：Current evidence sugeststhatlifestyleinterventionscanefectivelyimprovemetabolicsyndrome-relatedindicatorsinpatientswithcardiometabolic multimorbidityingdatagesuchsideectsiplicityndosiveess.owerefcacyofetio lasting less than 3 months requires further validation.

Keywordslifestyle；cardiometabolic multimorbidity；metabolic syndrome； Meta-analysis； evidence-based nursing

心血管代谢性共病（cardiometabolic multimorbidity，CMM是指个体同时存在2种及以上的心血管代谢性疾病（cardiometabolicdiseases，CMD），包括但不限于糖代谢疾病（2型糖尿病或糖调节受损）、脑卒中、脂代谢疾病（高胆固醇血症或高三酯甘油血症）冠心病、原发性高血压等[1]。（剩余11885字）