序贯肠内营养支持对脑卒中病人营养状况及康复效果影响的Meta分析

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Sequential enteral nutrition support on nutritional status and rehabilitation effect of stroke patients：a Meta-analysis

GUO Yale，LI Junwen，WANG Zhaolan，ZENG Xiang，WANG KunChengdu University of Traditional Chinese Medicine，Sichuan 610000 ChinaCorresponding Author  LI Junwen，E-mail：1018726540@qq.com

Abstract  Objective：To systematic evaluation the impact of sequential enteral nutrition support on the nutritional status and rehabilitation outcomes of stroke patients.Methods：Randomized controlled trials on sequential enteral nutrition support for stroke patients were retrieved from Chinese and English databases such as CNKI，VIP，CBM，WanFang Database，PubMed，Web of Science，the Cochrane Library，EMbase.RevMan 5.3 was used to conduct a Meta-analysis of literature that met the criteria.Results：A total of 12 articles were included，including 1 103 stroke patients.The Meta-analysis results showed that sequential enteral nutrition support can improve patients′ levels of prealbumin（MD=35.28，95%CI 15.30-55.27，P<0.005），serum albumin（MD=6.87，95% CI 6.52-7.23，P<0.000 1），and hemoglobin（MD=8.91，95%CI 8.34-9.48，P<0.000 01）;reduce the National Institute of Health Stroke Scale（NIHSS） score（MD=―2.75，95%CI ―4.53-―0.97，P=0.002）;reduce the incidence of lung infections（RR=0.50，95%CI 0.34-0.73，P=0.000 3），intestinal infections（RR=0.43，95%CI 0.26-0.72，P=0.001），urinary tract infections （RR=0.43，95%CI 0.24-0.77，P=0.005），and gastrointestinal complications（RR=0.42，95%CI 0.31-0.57，P<0.0 001）.Conclusion：Current evidence shows that compared to conventional nutritional support，sequential nutritional support can increase the nutritional level，improve immune function，and reduce complications in stroke patients.

Keywords  stroke;sequential enteral nutrition;rehabilitation;Meta-analysis;evidence-based nursing

摘要  目的：系统评价序贯肠内营养支持对脑卒中病人营养状况及康复效果的影响。（剩余9470字）