用于骨修复中可降解生物陶瓷的制备与性能优化

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中图分类号：TH114 文献标志码：A

DOI： 10.7652/xjtuxb202506009 文章编号：0253-987X（2025）06-0082-11

Preparation and Performance Optimization of Biodegradable Bioceramics for Bone Repair

ZHAO Yue1，ZHAO Yinan²，XU Yan1 ，CHEN Yutong1，YIN Zhitao¹ ， CHAO Jian¹ ，ZHOU Jianping1 （1.School of Mechanical Engineering，Xinjiang University，Urumqi 830ol7，China； School of Materials Science and Engineering，Huazhong University of Science and Technology，Wuhan 430074，Chin

Abstract： In response to the insufficient mechanical strength of calcium silicate in bone repair applications， a magnesium-doped calcium silicate ceramic material was prepared using a chemical precipitation method，and a bone repair scaffold with both excellent mechanical strength and biocompatibility was constructed. First，magnesium powder particles with diferent mass fractions were introduced into the calcium silicate powder，and the doping ratio of magnesium to calcium silicate powder was adjusted. Magnesium-doped calcium silicate ceramic materials were prepared by ball milling and de-binding sintering and other processes. Then，a 3D printing digital light processing（DLP） technique was used to print hollow cylinders with inner and outer diameters of 2.8mm and 5mm respectively， and a height of 6mm ，to construct bone scaffolds for bone repair. Finally，mechanical tests，CCK-8 cell proliferation assays，and alkaline phosphatase （ALP） tests were conducted to explore the effects of magnesium doping on the compressive strength and biocompatibility of biodegradable bioceramics. The experimental results showed that the elastic modulus of the magnesium-doped calcium silicate scaffold ranged from 94MPa to 110MPa ，which is 2.85 to 3.33 times that of the calcium silicate scaffold （ 33MPa . The cell viability of magnesium-doped calcium silicate scaffolds with mass fractions of （204号 5% and 10% ranged from 94% to 97% ，indicating good biocompatibility. In contrast， scaffolds with magnesium mass fractions of 15% and 20% exhibited cell viability below 70% ，which is unfavorable for cell proliferation. With a magnesium doping level of 10% and a sintering temperature of 1000∘C ， the magnesium-doped calcium silicate scaffold achieved the optimal combination of mechanical properties and biocompatibility.

Keywords： bioceramics； magnesium-doped calcium silicate scaffolds； digital light processing; compressive strength；biocompatibility

近年来，可降解生物陶瓷因其优异的生物相容性和生物活性，已成为骨修复和骨替代材料领域的研究热点[1]。（剩余15968字）