西洋参有效成分治疗急性肝损伤作用机制的网络药理学研究

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中图分类号：R285.5 文献标志码：ADOI：10.7652/jdyxb202504022

ABSTRACT： ObjectiveTo study the related key targets and main related signaling pathways of American ginseng in the treatment of acute liver injury by network pharmacology.MethodsThe main chemical components of American ginseng were found by the Traditional Chinese Medicine Systems Pharmacology（TCMSP） platform. The molecular formula of the components was obtained by Pubchem.The related target genes were obtained by SwissTargetPrediction，and the related targets of acute liver injury were collected by GeneCards database.Venny2.1 was used to obtain the intersection targets of drugs and diseases.The protein-protein interaction network was constructed by STRING online database and visualizedby Cytoscape 3.7.1 software.GO functional enrichment analysis and KEGG pathway enrichment analysis were performed on the David website. ResultsThrough data analysis，theresearch group obtained10 efective components of American ginseng，33odrug-related targets，7795 acuteliver injurydisease-related targets，and291 drug-disease intersection targets.The treatmentof acute liver injury by American ginseng mainly played a role through 216 biological processs，involving 3Ocell compositions，44 molecular functions，and 116 signaling pathways. ConclusionAmerican ginseng mainly treats acute liver injury by regulating key proteins such as mitogen-activated protein kinase 3 （MAPK3）， vascular endothelial growth factor A （VEGFA），heat shock protein 90AAl（HSP9oAAl），Caspase-3，signal transducer and activator of transcription 3 （STAT3），and intervening PI3K-Akt signaling pathway，cancer pathway，MAPK signaling pathway and other signaling pathways.

KEY WORDS： traditional Chinese medicine； American ginseng；acute liver injury；anti-oxidation；network pharmacology

急性肝损伤是指肝细胞在病毒、药物、寄生虫等因素作用下引起肝细胞急性损伤或坏死的疾病。（剩余12279字）