胱抑素C水平与我国中老年人帕金森病发病风险关系的纵向队列研究

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中图分类号：R742.5 文献标志码：ADOI：10.7652/jdyxb202504015

ABSTRACT：Objective To investigate the relationship between serum cystatin C（CysC） level and the risk of Parkinson’s disease （PD） in middle-aged and elderly people in China. MethodsBased on the baseline survey data fromthe China Health and Retirement Longitudinal Study（CHARLS）in 2O11，participants who were not diagnosed with PD at the time of the baseline survey were recruited.The onset of PD was tracked and folowed up until 2020， and the participants were divided into PD group and non-PD group according to whether they were newly diagnosed with PD in 2O2o.Multivariable Logistic regression analysis was performed to assess the assciation between serum CysC level and the risk of PD.Subgroup and interaction analyses were performed to ass effect modifications by age，gender and depresion.Additionally，restricted cubic spline（RCS）was used to explore the linear or non-linear relationship between serum CysC level and the risk of PD in different subgroups.ResultsWe included a total of 3 339 subjects in this study，who consisted of 1 495 males （44.77% ）and1844females 55.23% .While baseline participants were followed until 2O2o，32 subjects had a new PD，and the incidence of PD was 0.96% . The median age of PD group was 63.oO years.Multivariable Logistic regresson analysis found that CysC was an independent risk factor for the risk of PD，and CysC was positive significantly associated with the risk of PD（ OR=2.34 ， 95%CI ： 1.14-4.82 ， P=0.021 ）. Subgroup analysis showed that CysC was positively associated with PD in females （ OR= 2.70， 95% CI： 1.30-5.58 ， P=0.007 ）and subjects aged 6O years or older（ OR=5.29 ， 95% （202 CI ：1.69—16.53， P= 0.004）.RCS model indicated a linear relationship between serum CysC level and the risk of PD in females （ Ptotal= （20 0.018 ， Pnon-linear=0.062 ）and subjects aged 6O years or older （ ， Pnon-linear=0.379） .Conclusion High level of CysCmay increase the risk of PDin middle-aged and elderly people，especially infemales and those aged 60 years or older.

KEY WORDS：cystatin C（CysC）；Parkinson’s disease （PD）； China Health and Retirement Longitudinal Study（CHARLS）

帕金森病（Parkinson'sdisease，PD）是一种常见的神经退行性疾病[1]，在神经退行性疾病中的发病率仅次于阿尔茨海默病。（剩余9519字）