用于试纸条检测心梗标志物的PS微球制备及性能研究

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中图分类号：TB32 文献标志码：A

文章编号：2096-2983（2025）04-0049-06

引文格式：，．用于试纸条检测心梗标志物的PS微球制备及性能研究[J]．有色金属材料与工程，2025，46（4）：49-54. DOI：10.13258/j.cnki.nmme.20240313002.GUAN Shengwen， XU Jingcheng.Preparationand propertiesof polystyrene microspheresused fordetecting myocardialinfarctionmarkers bytransversechromatographyflow[J].Nonferous MetalMaterials and Engineering，2025， 46（4）： 49-54.

Abstract： Polystyrene （polystyrene microsphere， PS） microspheres possess small particle size， large specific surface area， excellent dispersion，and facile modification. They are commonly employed in medical diagnostics and hold potential as detection materials in transverse chromatographic flow analysis. This study aims to prepare PS microspheres meeting the requirements for transverse chromatographic flow analysis by adjusting factors such as temperature and emulsifier and monomer dosage，and the PS microspheres was carboxylated and fluorescent labeling through seed modification and sweling， ultimately applied in the development of a transverse chromatographic flow detection strip.The successful preparation of PS microspheres with a particle size of approximately 50nm was achieved，and the feasibilityof fluorescence-based carboxylated PS microspheres for quantitatively detecting marker concentrations on test strips were successfully demonstrated.

Keywords：polystyrene; emulsion polymerization; seed modification; lateral flow immunochromatography

发生急性心肌梗死的病人，从发病到死亡只需数个小时。（剩余8728字）