金属纳米材料在microRNA电化学传感器中的应用进展

打开文本图片集

中图分类号：TP212.3 文献标志码：A

文章编号：2096-2983（2025）04-0020-08

引文格式：，，．金属纳米材料在microRNA电化学传感器中的应用进展[J]．有色金属材料与工程，2025， 46（4）： 20-27.DOI： 10.13258/j.cnki.nmme.20240407001.OUYANG Ruizhuo， HUANG Ying， MIAO Yuqing.Recent advances in metal nanomaterial-based electrochemicalsensors for microRNA detection[J].NonferousMetal Materialsand Engineering， 2025， 46（4） ： 20-27.

Abstract： As a fluid biopsy analyte， microRNA （miRNA） exists in saliva， plasma urine， and other body fluids，and is related to various diseases， including cancer.It is an ideal biomarker for early clinical diagnosis of cancer. Among the various techniques for the detection of miRNA，electrochemical detection technology has been proved to be a potential detection method because of its low cost， easy miniaturization，and high sensitivity.In particular， the use of metal nanomaterials greatly improves the sensitivity of miRNA sensors and promotes the rapid development of electrochemical detection of miRNA. In this paper， the advantages and disadvantages of metal nanomaterials in the field of miRNA are discussed， the application and challenges of metal nanomaterials-mediated miRNA electrochemical sensors are reviewed， and its practical application prospect is prospected.

Keywords： metal nanomaterials; microRNA; electrochemical sensor

MicroRNA（miRNA）是一类内源性非蛋白质编码的单链小RNA分子，可以在翻译水平或转录后水平调节基因的表达，参与动植物转录后基因表达的调控。（剩余14687字）