Au纳米颗粒形貌调控工艺及SERS性能研究

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中图分类号：0657.37 文献标志码：A

文章编号：2096-2983（2025）04-0028-13

引文格式：，，．Au纳米颗粒形貌调控工艺及 SERS性能研究[J]．有色金属材料与工程，2025，46（4）：28-40．DOI： 10.13258/j.cnki.nmme.20240107001.TIAN Yuecheng， HE Bin， WANG Ding.Tailoring Au nanoparticle morphology for enhanced SERS performance： process optimizationandcharacterization[J].Nonferrous Metal Materials and Enginerng，2025， 46（4）： 28-40.

Abstract： Rapid and accurate detection of acute myocardial infarction （AMI） can significantly enhance patient survival rates. While cardiac troponin I （cTnl） and myoglobin （MyO） serve as conventional biomarkers，miRNA（MicroRNA） has emerged as a crucial early diagnostic biomarker for heart attacks.However， current routine immunodetection methods， such as real-time fluorescence quantitative polymerase chain reaction （PCR）， exhibit limited sensitivity and are time-consuming， hindering the achievement of high-sensitivity quantitative miRNA analysis. Surface Enhanced Raman Scattering （SERS） stands out as an exceptional fingerprint diagnostic technology， offering ultra-sensitivity， rapid response，and qualitative and quantitative analytical capabilities. In this study， the correlation between performance and modulation factors was explored through the manipulation of various morphologies of the noble metal Au. Leveraging the electromagnetic field enhancement and chemical enhancement mechanisms， we designed a simple and easily manufacturable efficient gold nanospheres （Au NSs） NSs SERS biosensing substrate. This substrate was successfully employed for the gradient concentration testing of miRNA， demonstrating remarkably low detection limits and high sensitivity.

Keywords： acute myocardial infarction; miRNA; surface-enhanced Raman scattering; gold nanoparticles；bioassays.

根据世界卫生组织报告，急性心肌梗死（acutemyocardialinfarction，AMI）被认为是世界范围内心血管疾病死亡的最主要原因之一[。（剩余12393字）