基于引入疏水官能团调节MOF涂层的水稳定性和抗菌性能研究

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中图分类号：TG111;R318.08 文献标志码：A

文章编号：2096-2983（2025）04-0041-08

引文格式：，，．基于引人疏水官能团调节MOF涂层的水稳定性和抗菌性能研究[J]．有色金属材料与工程， 2025，46（4）：41-48.DOI： 10.13258/j.cnki.nmme.20240315001.CHAIYuzhen，MA Fengcang，SONG Wenxuan.Studyonthe waterstabilityand antibacterial propertiesofMOF coatingsregulatedbyintroducing hydrophobic functional groups[J]. Nonferrous Metal Materials and Engineering， 2025， 46（4）： 41-48.

Abstract： In the biomedical field， metal-organic frameworks （MOF） have atracted much attention due to their excelent design-ability and functionality. However， the stability of MOF in water medium is poor，and it is easy to degrade in acidic environment， which has become a difficult problem restricting its clinical application.In this study， electrodeposition and dip coating techniques were used to optimize the stability of MOF by introducing hydrophobic functional groups. On the titanium alloy to construct a kind of layered double hydroxide （LDH） and the surface of zeolite imidazole skeleton-8 （ZIF-8） consisting of double coating. LDH not only plays a protective role， but also strengthens the interface bonding strength between the botom layer and the surface layer ZIF-8. ZIF-8 acts like a layer of armor， effectively blocking the invasion of corrosive ions through microporous defects.the use of zinc base MOF and raloxifene hydrochloride （RHT）， the synergistic effect between the pure titanium surface construct both drug load and stability enhancement of multi-functional coating. The experiment shows that the coating was able to achieve continuous release of Zn2+ ions and RHT molecules for more than 14 days. The effective integration of MOF and RHT improves the stability of MOF in water environment.

Keywords： pure titanium; MOF coating; electrodeposition treatment; raloxifene; water stability

纯钛以其优良的性能被广泛应用于医疗器械和植入物中[1]。（剩余9871字）