茵栀黄颗粒联合布拉酵母辅助蓝光治疗56例新生儿高胆红素血症的临床疗效

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摘 要 目的：探讨茵栀黄颗粒联合布拉酵母辅助蓝光治疗新生儿高胆红素血症（NHB）的临床疗效。方法：将112例NHB患儿随机分为对照组（n=56）和观察组（n=56），对照组采用蓝光间歇照射治疗，观察组在此基础上给以茵栀黄颗粒联合布拉酵母口服治疗，比较两组患儿的临床疗效。结果：观察组总有效率96.43%，显著高于对照组的89.29%；黄疸消失时间、皮肤颜色恢复正常时间和平均住院时间显著低于对照组；治疗后两组血清总胆红素（TSB）、直接胆红素（DBIL）、总胆汁酸（TBA）水平均有所下降，且观察组的下降程度优于对照组（均P

关键词 茵栀黄颗粒 布拉酵母 高胆红素血症 蓝光

中图分类号：R286； R272.1 文献标志码：A 文章编号：1006-1533（2022）01-0025-03

Clinical effect of Yinzhihuang granules combined with Saccharomyces boulardii plus assistance of blue light in the treatment of 56 cases of neonatal hyperbilirubinemia

YAO Yao1， LIU Binbin1， WANG Pin2（1. Department of Pharmacy， Zhengzhou Maternal and Child Health Hospital， Zhengzhou 450012， China； 2. Department of Pediatrics， the Central Hospital of Nanyang， Nanyang 473000， China）

ABSTRACT Objective： To investigate the clinical effect of Yinzhihuang granules combined with Saccharomyces boulardii plus assistance of blue light in the treatment of neonatal hyperbilirubinemia （NHB）. Methods： One hundred and twelve patients with NHB were randomly divided into a control group （n=56） and an observation group （n=56）. The control group was treated with intermittent blue light irradiation while the observation group was additionally treated with Yinzhihuang granule combined with Saccharomyces boulardii. The clinical efficacy was compared between the two groups. Results： The overall response rate was significantly higher in the observation group than the control group （96.43% vs 89.29%）. The times for jaundice disappearance， skin color recovery and average hospital stay were significantly lower in the observation group than the control group. The levels of serum total bilirubin （TSB）， direct bilirubin （DBIL） and total bile acid （TBA） in both groups were decreased after treatment， and furthermore the degree of decline was better in the observation group than the control group （all P

KEy wORDS Yinzhihuang granules； Saccharomyces boulardii； hyperbilirubinemia； blue light

新生兒高胆红素血症（neonatal hyperbilirubinemia， NHB）又称新生儿黄疸，是一种新生儿常见的疾病，母体因素是导致该病发生的重要原因[1]。（剩余4121字）