不同剂量地佐辛在重症监护机械通气患者中的应用效果对比

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摘 要 目的：探讨不同剂量地佐辛在重症监护室（ICU）机械通气患者中的应用效果。方法：选择120例ICU机械通气患者，随机分为A、B、C组，各40例。A、B、C组常规治疗后分别给予1.0、2.0、3.0 mg/h地佐辛。观测三组给药前后生命体征、镇痛及镇静评分及不良反应情况。结果：B、C组给药1 d、2 d镇痛评分低于A组，B组给药8 h、1 d及2 d镇静评分均低于A、C组，C组给药8 h后呼吸频率低于A、B组，ICU及机械通气时间高于A、B组，A组联合用药比例高于B、C组（P

关键词 重症监护 机械通气 地佐辛 剂量

中图分类号：R971.2 文献标志码：A 文章编号：1006-1533（2022）01-0015-04

Comparison of the effect of different doses of dezocine in patients with mechanical ventilation in intensive care unit

ZHU Like， YE Peijun

[Department of Critical Care Medicine， Tumor Hospital affiliated to Zhengzhou University（He’nan Tumor Hospital）， Zhengzhou 450000， China]

ABSTRACT Objective： To explore the effect of different doses of dezocine in mechanically ventilated patients at the intensive care unit. Methods： A total of 120 mechanically ventilated ICU patients were selected and randomly divided into groups A， B， and C with 40 cases each. Groups A， B， and C were given 1.0， 2.0， 3.0 mg/h dezocine after conventional treatment， respectively. The vital signs， analgesia and sedation scores and adverse reactions in the three groups were observed before and after administration. Results： The analgesic scores were lower in group B and C than group A on the first and second days of administration. The sedation scores were lower in group B than group A and C at 8 h， 1 d and 2 d after administration. The respiratory rate was lower in group C than group A and C 8 h after administration. The times for ICU stay and mechanical ventilation were longer in group B than group A and B. The proportion of combined medication was higher in group A than group B and C （P

KEy wORDS intensive care； mechanical ventilation； dezocine； dose

重癥监护室（ICU）机械通气患者往往病情较为严重，因疾病本身及治疗常带来常人难以忍受的疼痛[1]，适当给予镇静、镇痛药可缓解患者痛苦，提高治疗依从性。（剩余4744字）