环孢素软胶囊联合阿维A胶囊对银屑病的治疗效果及VEGF、IFN-γ、PASI分析

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【摘 要】目的：分析针对银屑病的治疗中使用环孢素软胶囊和阿维A胶囊的效果。方法：选取在本院就诊的80例银屑病患者，经随机数字抽选法分组后，予以对照组（40例）环孢素软胶囊治疗，观察组（40例）环孢素软胶囊联合阿维A胶囊治疗，比较两组治疗前后VEGF、IFN-γ、PASI评分变化及治疗有效率。结果：两组患者治疗前VEGF、IFN-γ、PASI评分对比结果无统计学差异（P>0.05）；治疗12周后，观察组的以上指标水平下降（95.45±10.25 ng/ml、9.45±1.65 ng/ml、5.31±1.29分），且明显低于对照组（118.54±15.58 ng/ml、13.05±2.17 ng/ml、7.69±1.54分）（P

【关键词】环孢素软胶囊；阿维A胶囊；银屑病；VEGF；IFN-γ；PASI

Therapeutic effect of cyclosporine soft capsule combined with acitretin capsule on psoriasis and analysis of VEGF， IFN-γ， PASI

KONG Shujing1， HUANG Yan2

1.Department of Dermatology， Affiliated Hospital of Xuzhou Medical University， Xuzhou， Jiangsu 221000， China

2.Department of Neurology， Affiliated Hospital of Xuzhou Medical University， Xuzhou， Jiangsu 221000， China

【Abstract】Objective： To analyze the effects of cyclosporine soft capsules and acitretin capsules in the treatment of psoriasis. Methods： Select 80 patients with psoriasis in our hospital， grouped by random number selection， and treated with cyclosporine soft capsule in the control group （40 cases）， cyclosporine soft capsule combined with acitretin capsule in the observation group （40 cases）， compare the changes of VEGF， IFN-γ， PASI scores and the effective rate of treatment between the two groups before and after treatment. Results： The comparison results of VEGF， IFN-γ and PASI scores of the two groups of patients before treatment were not statistically different（P>0.05）； after 12 weeks of treatment， the levels of the above indicators in the observation group（95.45±10.25 ng/ml， 9.45±1.65 ng /ml， 5.31±1.29 points） decreased， and significantly lower than the control group （118.54±15.58 ng/ml， 13.05±2.17 ng/ml， 7.69±1.54 points）（P

【Key？Words】Cyclosporine soft capsules， Acitretin capsules， Psoriasis， VEGF， IFN-γ， PASI

银屑病属于慢性炎症性皮肤疾病的一种，且较为常见，其临床症状主要为有银白色鳞屑的皮肤红斑，全身均可发病，病程漫长，症状可在反复性发作后加剧，且症状发作具有季节性特征，且临床表现类型多样，尚无法根治，故现阶段治疗主要倾向于对患者病情的缓解，减少复发次数，促进病情的恢复[1-2]。（剩余3042字）