基于网络药理学探讨黄芪治疗对虾白斑综合征的作用机制

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DOI：10.3969/j.issn.1004-6755.2025.07.002

Based on network pharmacology discuss the mechanism of Astragali Radix in treatment of white spot syndrome in shrimp

CHEN Linzi

（Fujian Provincial Aquatic Technology Extension Station，Fuzhou 35ooo2，China）

Abstract：Using the Herb，Swiss Target Prediction，and PharmMapper databases to predict potential targets for the active ingredient 13- hydroxy-9，1l-octadecadienoic acid from Astragali Radix，and combining this with the DisGeNET，GeneCards，and OMIM databases to screen for targets related to shrimp white spot syndrome，we identified 52 intersecting targets. Through STRING，a PPI network was constructed，and Cytoscape selected the TOPl0 core targets，including tnfb， pparg，and bcl2a. GO and KEGG analyses indicate that this component may regulate functions such as antioxidant stress，inflammation，and cellcycle through signaling pathways like FoxOand Peroxisome.Molecular docking results show that the active ingredient 13- hydroxy-9，11-octadecadienoic acid from Astragali Radix can stably bind to key targets，supporting its potential in preventing and treating shrimp white spot syndrome.

Key words： Astragali Radix ；13-hydroxy-9，11- octadecadienoic acid；white spot syndrome in shrimp；network pharmacology；molecular docking

对虾白斑综合征自20世纪90年代爆发以来，对我国对虾养殖业造成了严重威胁[1]，其病原白斑综合征病毒（white spot syndrome virus，WSSV）宿主广泛，不仅感染对虾，还可影响龙虾、螯虾、蟹等甲壳类生物，严重影响了虾蟹养殖业的可持续发展[2]。（剩余3935字）