间充质干细胞用于牙周再生临床疗效的系统评价与Meta分析

[中图分类号]R781.4 [文献标志码]A [doi] 10.7158/gjkq.2025024

Clinical efficacyof mesenchymal stem cels onperiodontal regeneration： a systematic review and meta-analysis

LiTianyuan1，2，ZhuTongxin2，LiuQing，DongYingchun3，ChenBin2

1.Dept.ofStomatology，the94thHospitalofJointLogisticsUnitoftheChinesePeople'sLiberationArmy，Changzhou 213，Cia；.eptridtologyjngtotologicalHostaldicalolfjingUity searchIsieoittlo logical HositaldicalooloingUvsityearchsiteofotologingvsit 218，China

Supported by：National Natural ScienceFoundationofChina （824l135）；Natural ScienceFoundationofJiangsu Pro vince （BK222199）；Nanjing Health Scienceand Technology Development SpecialFund Project （ZKX2254） Correspondence： Chen Bin， Email： 361734128@qq.com

[Abstract]ObjectiveThis studyaimed tocompare thedifferences inclinical attachment level （CAL），periodontal probing depth （PPD），gingivalrecesion（GR），andbone defect depth （BDD）between patients undergoing periodontalsurgeries withand without mesenchymal stemcells （MSCs）andto evaluate the clinical efficacyofMSCs in periodontal regenerationthroughameta-analysis.MethodsPubMed，CochraneLibrary，Embase，Scopus，CNKI，Wanfang Data，and

CBMwere comprehensively searched for randomized controlled studies （RCTs） about MSC therapy for periodontal defectsin patientswith periodontitisuptoApril 1，224.Literature selection，data collection，and evaluationofbiaswereconductedbytworesearchers independently，and thendata were analyzed through RevMan

5.4 software and Stata15.1 software.ResultsSix studies were enrolled.The meta-analysis results showed that the experimental group had more significant improvement in CAL and decrease in PPD and BDD （ P< . 5 ） .However， nosignificant difference was found in efficacy between the two groups in terms of GR （ ）.Conclusion Compared with traditionalperiodontalregeneration methods，theapplicationofMSCs mayhavesomeadvantages.However，potential heterogeneityamong theincludedRCTsandlimitations onthequantityandqualityofthese studies necessitatecautious interpretationofthe findings.Further high-qualityRCTs withalarge sample size andamulticentral characterarerequiredto prove the efficacy of MSCs in periodontal regeneration.

[Key words] mesenchymal stem cell；periodontal regeneration；periodontitis；alveolar bone loss

牙周炎是一种导致牙周支持组织丧失的慢性炎症性疾病，是成年人牙齿丧失的主要原因。（剩余20882字）