Zn,AI-CDs对四环素类抗生素的超灵敏荧光检测

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中图法分类号：0652.7 文献标识码：A 文章编号：1000-2324（2025）03-0444-08

Abstract：Tetracycline antibiotics（TCs）are widelyused in medicineand aquaculture.Theirresidues poseathreat to food safetyand theecologicalenvironment.Therefore，itiscrucialtodevelopeficientandsensitive detectionmethods forTCs. This study utilizes sodium citrate as the carbon source， incorporates Zn and Al doping，and synthesizes carbon dots （Zn， AlCDs）through a hydrothermal method.By employing these carbon dots as fluorescent probes，ultrasensitive fluorescence detectionofTCisachieved. WiththeincreaseofTCsconcentration，the detectionsystemexhibitsgreen fluorescene，anda good linear connectionisobserved betwen fluorescence intensityandTCs concentration.The detection system has linear ranges of 0.01～7μM ， 0.01～7μM 0.01～5μM ，and 0.01～7μM fortetracycline hydrochloride （TCH），chlortetracycline hydrochloride（CTC），oxytetracycline hydrochloride（OTC），anddoxycyclinehydrochloride（DOC），respectively，with detection limits of 5.6nM ，7.41 nM， 4.28nM and 13.5nM ，respectively.Different types of tetracyclines are distinguished by the emisson wavelengthof thesystemic fluorescence.Inaddition，the Zn，Al-CDs material issuccessfullyappliedto detectTCH intapwater，river waterand milk，and the paper-based sensor prepared with Zn，Al-CDscanachieve semiquantitativevisualdetectionofTCs，ndicatingthematerial'spotentialasaqualitativeandquantitativedetectionssorfor tetracycline antibiotics.

Keywords：Tetracyclines;carbondots;detection;fluorescence

TCs作为一类广谱抗生素，由于其优异的抗菌性和低廉的成本，已被广泛用应于农业养殖业，用于预防和治疗疾病。（剩余10292字）