阿尔茨海默病发病机制的研究进展

［摘 要］ 随着我国人口老龄化问题的日趋严重，与衰老密切相关的老年痴呆人数也不断增长，阿尔茨海默病（AD）是引起老年痴呆最常见的病因，对患者及家庭造成了严重的经济和精神负担，因此对于脑衰老及AD的研究已经成为迫切需求。本文就近年来AD的发病机制进行综述，为脑衰老造成的神经退行性AD等疾病提供参考。

［关键词］ 脑衰老；发病机制；神经退行性疾病；阿尔茨海默病  doi：10.3969/j.issn.1674-7593.2024.05.021

Advancements in the Pathogenesis Research of Alzheimers Disease

Lu Xi 1，Luo Xiaofeng 2，Song Yu 3，Liu Yongchao 1，Sun Xin 3，Li Chunying2**1 Medical Technology College of  Beihua University， Jilin 132000；2 Basic Medical College， Jilin Medical University，Jilin 132000； 3College of Pharmacy， Jilin Medical University， Jilin 132000

**Corresponding author：Li Chunying，email： lcythunder@163.com

［Abstract］ With Chinas aging population on the rise， the incidence of senile dementia， particularly neurodegenerative diseases Alzheimers disease （AD）， is also increasing， leading to significant economic and emotional burdens for patients and their families.Consequently， research on brain senescence and AD has become imperative.This review delves into recent advancements in understanding the pathogenesis of AD， offering crucial insights into the neurodegenerative processes associated with brain senescence and informing strategies for managing and treating AD and related conditions.

［Key words］ Brain senescence;Pathogenesis;Neurodegenerative diseases; Alzheimers disease

我国老年人口基数大，2020年65岁及以上的老年人口达到1.91亿，2022年的老龄化率达到14%，预测2030年前后将达到20%［1］。（剩余15619字）