干扰素刺激基因在肿瘤免疫中作用机制的研究进展

［摘 要］ 干扰素刺激基因（ISGs）是一种经干扰素诱导、刺激后显著表达的基因。可通过免疫抑制分子的浸润，免疫检查点抑制，免疫编辑等方式抑制或者促进肿瘤细胞的生长浸润。本文对ISGs在肿瘤免疫中的具体作用机制及其在肿瘤药物治疗中发挥的作用作一综述，有望为开发更为精准的治疗策略提供理论基础。

［关键词］ 干扰素刺激基因；免疫检查点抑制；免疫抑制分子；肿瘤药物  doi：10.3969/j.issn.1674-7593.2024.05.018

Breakthroughs in the Roles of Interferon-stimulated Genes in Tumor Immunity

Cao Fadi  Li Fan

College of Basic Medical Sciences， Jilin University， Changchun 130021

**Corresponding author： Li Fan，email： lifan@jlu.edu.cn

［Abstract］ Interferon-stimulated genes （ISGs） are crucially expressed in response to interferons and play pivotal roles in tumor immunity.These genes can either inhibit or promote tumor growth and infiltration by modulating immunosuppressive molecules， immune checkpoint inhibition， and immune editing.This review examines the specific mechanisms through which ISGs influence tumor immunity and their impact on oncological drugs， aiming to provide a theoretical foundation for developing more precise treatment strategies.

［Key words］ Interferon-stimulated genes; Immune checkpoint inhibition; Immunosuppressive molecules; Oncological drugs

干扰素（Interferon，IFN）是一种具有抗病毒、抗肿瘤、免疫调节和促细胞分泌等多方面作用的细胞因子，根据其结构特征、受体、细胞来源和生物活性，分为3种类型IFN-Ⅰ、IFN-Ⅱ和IFN-Ⅲ。（剩余10662字）