光声遥感弹性成像检测支气管纤维化生物力学特性

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中图分类号：0436 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.03.006

Abstract：Obstructivebronchitis isafibrotic diseaseofthelungs thatoccurs inresponse to inhalationofnoxious gases， immune dysfunctionandlungorbone marrowtransplantation.Fibrosisisapathologicalhallmarkofobstructivebronchiis，nd alterations initsmechanicalpropertiesplayakeyroleinunderstandingthepathologicalprogressionofobstructivebronchitis. Duetothelackofstudiesrelatedtothemechanical propertiesofobstructivebronchitis，litleisknownabout thepathological mechanismsinthisarea.Therefore，inthispaper，toadresstheaboveproblem，photoacousticremotesensingelastographywas usedtoimagethebiomechanicalpropertiesofbronchialfibrosis.Theresultsshowedthattherisetimesofphotoacousticsignals correspondingtonormalbronchialtubesaswellasbronchialtubesintheearlymiddle，ndlatestagesoffibrosis were113ns， 107ns，96nsand7Onsespectielyndasortrisetieresultedinalargeelasticmodulus;theelasticmodusootic bronchialubes waslarger thanthatofnormalbronchialtubes，andtheelastic modulus inthethreestagesoffibrosisincreased sequentiall fromtheearlystage tothelate stage.Inthis paper，thechangesofbronchial mechanical properties during the processofobstructive bronchitis were investigatedandtherelativevaluesofelastic modulus were extractedtoproposea new reference for the graded diagnosis and prevention of obstructive bronchitis.

Key words： biological optics; photoacoustic imaging; elastic imaging; photoacoustic remote sensing; bronchial fibrosis

（ActaLaser BiologySinica，2025，34（3）：239-245）

闭塞性支气管炎（bronchiolitisobliterans，BO）是一种以小气道狭窄和阻塞为特征的纤维化肺部疾病[1]，最常见于肺移植或骨髓移植的患者，但也有患者因职业原因暴露于活性挥发性化学物质而发病。（剩余11366字）