微生物-肠-心轴”与心血管疾病相关性的研究进展

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中图分类号：R54 文献标志码：A DOI：10.3969/j.issn.1007-7146.2025.03.003

Abstract：Cardiovasculardisease iscurrentlytheleadingcauseofdeath inthe world，andalthoughgreatprogresshas been made ntheresearchandclinicaltreatmentofitspathogenesis，themortalityrateisstillhigh，andnew waysofscientific interventionareurgentlyneeded.Intestinalflora is the most numerous andcomplex microbialcommunity in the humanbody， whichplaysanimportantroleinthealthyomeostasisofthebodyanditsimbalancecanleadtoavarietyofchonicdiseases includingcardiovasculardisease，andforma“microbiome-gut-heartaxis”relationship，whichspeculates thatintestinalflora anditsmetabolitesmaybepotentialbiologicaltargetsforthe treatmentofcardiovasculardisease.Thisarticlefocusesonthe regulatorymechanismbetween the“microbiome-gut-heartaxis”andcardiovasculardisease，andproposes the preventionand treatmentofcardiovasculardiseases fromtheperspectiveofintestinalmicrobiota，inorder toprovidereferenceforclinical treatment.

Keywords：gutmicrobes;cardiovasculardiseases;microbiome-gut-heartaxis;intestialflora metabolites;novelcoroavirus （ActaLaser Biology Sinica，2025，34（3）：214-220）

心血管疾病（cardiovasculardisease，CVD）是一种高发病率、高致残率、高死亡率及高复发率的疾病，是导致我国居民死亡的主要原因。（剩余15093字）