保妇康栓联合重组人干扰素治疗慢性宫颈炎合并HPV感染的有效性及安全性的Meta分析

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关键词：保妇康栓；重组人干扰素；慢性宫颈炎；人乳头瘤病毒；Meta分析；中西医结合疗法中图分类号：R246.3文献标志码：A文章编号：1003-9783（2025）09-1585-10doi： 10.19378/j.issn.1003-9783.2025.09.017

Effcacyand Safety of Baofukang Suppository Combined with Recombinant Human Interferon in Treating Chronic Cervicitis with HPV Infection：A Meta-Analysis

LIU Xinyu1，HUANG Linqi²，DENG Gaopi（1. Beijing Chaoyang Hospital Affiiated to Capital Medical University， Beijing10O02O，China；2.The First School of Clinical Medicine，Guangzhou University of Chinese Medicine， Guangzhou 510405 Guangdong，China；3.The First Afiliated Hospital of Guangzhou Universityof Chinese Medicine， Guangzhou 510405 Guangdong，China）

Abstract：ObjectiveTo systematically evaluate the efficacy and safety of Baofukang Suppository combined with recombinant human interferon （IFN）in treating chronic cervicitis with human papillomavirus（HPV） infection. Methods Randomized controlled trials（RCTs） investigating Baofukang Suppositorycombined with IFN for chronic cervicitisand HPV infection were retrieved from CNKI，Wanfang，VIP，PubMed，Cochrane Library，and Embase databases from inception to February 26，2025.Studies were screened based on inclusion/exclusion criteria，and relevant data were extracted.Meta-analysis was performed using RevMan 5.3 software.Results Twenty studies involving 1864 patients were included.The Meta-analysis demonstrated that compared with the control group（IFN alone），the trial group （Baofukang Suppository + IFN）significantly improved clinical response rate [RR =0.28 ， 95% CI （0.20，

0.38）， P<0.000 01. ，cure rate[RR=0.80， 95% CI（O.73，O.88），P0.05 ）.Conclusion Baofukang Suppository combined with IFN enhances clinical efficacy and HPV clearance while reducing inflammatory markers，with a favorable safety profile.However，potential biases in some studieswarrant furtherhigh-quality RCTs for validation.

Keywords：Baofukang Suppository；recombinant hunman interferon suppository chronic cervicitis；human papillmavirus （HPV）；Meta-analysis； integrated Chinese and western medicine therapy

慢性宫颈炎是临床妇科常见疾病，其中人乳头瘤病毒（HPV）是导致慢性宫颈炎的重要病原体之一。（剩余11161字）