膀胱癌中长链非编码RNA对Wnt/β-catenin信号通路调控的研究进展

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Research progress on the regulation of the Wnt/ β -catenin signaling pathway by LncRNAs in bladder cancer

LI Rui，WANG Fei，WANG Weifu

（Department of Urology，Hainan Provincial People's Hospital，Hainan Medical University Hainan Hospital，

Haikou ，China）

ABSTRACT： Bladder cancer has a complex pathogenesis involving the dysregulation of multiple signaling pathways.The malignant progression of bladder cancer is closely asociated with the aberrant activation of the Wnt/β -catenin signaling pathway，which isregulatedbylongnon-coding RNAs（LncRNAs）atmultiple levels，fecting tumor proliferation，metastasis， and drug resistance.LncRNAs regulate the Wnt/β-catenin pathway through three main mechanisms.Firstly， β. -catenin stability， where SNHG7 inhibits GSK3β-mediated degradation，promoting nuclear accumulation of β. catenin，whereas GAS5 enhances its degradationvia the miR-18a-5p/AXIN2 axis.Secondly，regulationof downstream target genes，with oncogenic LncRNAs such as CASC9 and PVTlactivating cyclin Dland MMPs through miRNA sponging，driving epithelial-mesenchymal transition（EMT） and invasion，while the tumor-suppressive LncRNAs miRl43HG inhibits β -catenin nuclear translocation.Thirdly，crosstalk with other signaling pathways，as exemplified by CARLo-7，which simultaneously activates both the wnt/β. -catenin and JAK2/STAT3 pathways，exacerbating the malignant phenotype.As potential biomarkersand therapeutic targets，LncRNAshave demonstrated promising potential in preclinical models.Thisreview summarizes thekeyLncRNAs involved in bladdercancerand their mechanisms in regulating the Wnt/ β. -catenin pathway，providing new insights for the precise treatment of bladder cancer.

KEY WORDS： bladder cancer; long non-coding RNA; Wnt/ 'β -catenin；signaling pathway；targeted therapy

摘要：膀胱癌发病机制复杂，涉及多个信号通路的异常调控。（剩余13059字）