脐尿管癌75例临床诊疗及预后因素分析

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Analysis of clinical diagnosis， treatment and prognostic factors in 75 cases of urachal carcinoma

ZHANG Yong，CUI Lingang，YUAN Penghui，LYU Tianyu，CUI Jiahao，ZHAO Zhuo，MENG Qingjun （Department of Urology，The First Afiliated Hospital of Zhengzhou University，Zhengzhou 450052，China）

ABSTRACT：ObjectiveTo explore the diagnosis，treatment and prognostic factors of urachal carcinoma （UrC），aiming to providereference for the standardized diagnosis and treatmentof this disease.MethodsAretrospective analysis was conducted on the clinical data of 75UrC patients confirmed with postoperative pathology treated in our hospital during Mar. 2010and Mar.2O23.Allpatientsunderwent surgical treatment，and 35received postoperativechemotherapy.Univariateand multivariateCoxregresionanalyseswereperformed to identify independentprognostic factors.Kaplan-Meiercurves were adopted to calculate thecumulative survival rates and overall survival（OS）.ResultsAmong the75 patients，themale to female ratio was 2.8：1 and the mean age was （58.4±2.2） years.Median follow-up was 6O months and median OS was 48 months.The 3-year survival rate was 67.3% and the 5-year survival rate was 38.8% .There were 19 cases 25.3% ）ofCK7 positive，60 cases （80.0% ） of Sheldon stage Il and above，and 26 cases （34.7% ）of postoperative recurrence.CK7 positive （ P=0.001 ），Sheldon staging I+N （ P=0.005 ）and postoperative recurrence（ P=0.003 ）were independent prognostic factors.ConclusionUrachal carcinomais arare malignant tumor in males with occult onset.CK7 positive，Sheldon staging and postoperative recurrence were independent prognostic factors of this disease.

KEY WORDS：urachal carcinoma；adenocarcinoma ofcolon;partialcystectomy;Sheldon staging；postoperative recurence;CK7摘要：目的探讨脐尿管癌（UrC）的诊疗特点和预后影响因素，为该疾病的规范化诊疗提供参考。（剩余9519字）