原发性醛固酮增多症的临床诊治进展

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Advances in the clinical management of primary hyperaldosteronism

LIAO Huasheng1 ，WU Yizhao²，DENG Cai²，AO Zijian²，ZHANG Lichao1 （1.Department of Urology，The 12th People's Hospital of Guangzhou，Guangzhou 510799;2.Department of Urology，The Second Afiliated Hospital of Guangzhou Medical University，Guangzhou 5lOl2o，China）

ABSTRACT：Primary hyperaldosteronism（PHA），the most common cause of secondary hypertension，can lead to cardiovascularandrenal damageevents.Earlydiagnosisandaccurate typing of PHA is crucial to thechoiceof treatment options，nditsdagnostic modalitiesusuallyincludepronetestscreeningcaptopril testcharacterzationandadrenal vei blood sampling forlocalization and typing diagnosis.However，with the development of imaging，molecular biologyand morphology technologies，theuseof nuclear medicine PET-CT，genetic testing and pathological diagnostic methodscan alsobeusedto accurately typify PHA.New technologiessuchasadrenal artery embolization and adrenalradiofrequencyablationare also increasinglybeingused inthetreatmentof PHA，which have theadvantagesof shorterandlesscostlysurgery，fewer postoperativecomplications，and quickerrecovery.Thisarticle providesareviewof thedevelopments inthe screning，diagnosis and treatment of PHA with a view to informing clinical practice.

KEY WORDS：primary hyperaldosteronism；adrenal vein sampling；radiofrequency ablation；arterial embolization

摘要：原发性醛固酮增多症（PHA）——继发性高血压最常见的病因，可导致心脑血管及肾脏损害事件发生，对其早期诊断及精准分型之于治疗方案的选择至关重要。（剩余13700字）