溶瘤病毒及其载体用于膀胱癌治疗的研究进展

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Research advances on oncolytic viruses and their vectors for bladder cancer treatment

ZHAI Zhenxing，WANG Zhiping

（Department of Urology，Lanzhou University Second Hospital，Gansu Province Clinical Research Center for

Urinary System Disease，Lanzhou 73oooo，China）

ABSTRACT：Bladder cancer has the characteristics of multiple and easy recurrenceafter surgery.At present，the main treatmentmethodsincludesurgery，chemotherapyradiotherapy，ndsoon.However，therecurrencerateandmetastasisateare stillveryhigh，seriouslythreatening humanhealth.Oncolyticviruseshavebecomeanimportantpartofacomprehensivecancer treatment strategy.Compared with surgery，radiotherapyandchemotherapy，oncolytic virus therapy is more precise and les toxic，which isexpectedtosignificantly improve patients’qualityof life.However，thetherapeuticeffectsof oncolyticviruses alonearesatisfactory.Currentlyoncolyticvirusesarecombined with immunotherapy，chemotherapyorradiotherapy toimprove theoverall anti-tumorefects.Thecombinationofoncolyticviruses and immunotherapyhasarelatively broaderprospect.This articlereviews theresearch progressof theclinicalaplicationofadenovirus vctors，entiviral vectors，adeno-associatedvirus vectors，and oncolytic viruses combined with immunotherapy，chemotherapy，and radiotherapy for bladder cancer.

KEY WORDS： bladdercancer；oncolytic virus；viral vector；adenovirus vector；lentiviralvector；adeno-asociated virus vector；immunotherapy；chemotherapy；radiotherapy

摘要：膀胱癌具有多发、术后易复发的特点，目前膀胱癌的治疗方法主要包括手术、化学治疗、放射治疗等，但治疗后其复发率及转移率仍然很高，严重威胁人类健康。（剩余16747字）