头孢妥仑匹酯关键杂质的合成

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中图分类号：R978 文献标识码：A 文章编号：1001-8751（2025）02-0140-05

SynthesisoftheKeyImpurityofCefditoren Pivoxil

Zhou Jun-rong （Zhejiang DongbangPharmaceutical Co.，Ltd， Linhai Zhejiang ）

Abstract： ObjectiveStudy the synthesis method of key impurities incefotentin axetil.MethodsCefditoren pivoxil was used as the starting material.Then cefditoren pivoxil and chloro（methoxy） methane or iodomethyl pivalate was subjected to a condensation reaction to synthesize methoxymethyl cefditoren pivoxil or cefditoren dipivoxil. ResultThepurityof the products was relatively high.Additionally，it wassimple tocollect the basic ingredients needed for this method. ConclusionThe correctnessof the chemical structure of methoxymethyl cefditoren pivoxil and cefditoren dipivoxil was confirmed by IR， HR-MS and NMR.

Key words： cefditoren pivoxil；；synthesize；methoxymethyl cefditoren pivoxil； cefditoren dipivoxil； chemical structure

头孢妥仑匹酯属于第三代头孢菌素类口服抗生素，原研厂家为日本明治制果株式会社，国内仅原研口服（片剂与颗粒剂）制剂获批上市，商品名称为美爱克，市场潜力巨大。（剩余7757字）