PTX3调节胶质瘤TMZ耐药的研究进展

【中图分类号】 R739.41 【文献标志码】 A 【文章编号】 1672-7770（2025）03-0330-05

Abstract：Glioblastoma（GBM）isone of the most aggressive and lethal malignancies within thecentral nervous system，with therapeuticeffcacyoften limited bythedevelopmentofresistance.Temozolomide（TMZ）isthe cornerstonechemotherapeuticagentin the standard treatment regimen for GBM.However，the emergenceof TMZ resistance significantlyimpactspatient survival outcomes.Inrecent years，Pentraxin 3（PTX3），akeyregulatory factorwithinthe tumormicroenvironment（TME），has garneredwidespreadatentionforitsrole inthedevelopmentof resistance in GBM.PTX3not only promotes tumor survival and invasion by modulating immunecell polarization， redox balance，and the inhibitionof autophagy withinthe TME，butalso enhancetheresistanceof tumor cells to TMZ through interactions with multiple cellarsignaling pathways.This review discusss thespecificroleof PTX3 in the mechanisms of GBMresistance and explores its potential asa therapeutic target，aiming to provide new strategies and insights for overcoming GBM resistance.

Key words：glioblastoma；Pentraxin 3；tumor microenvironment；resistance mechanisms；redox balance; ：egulation of autophagy inhibition

胶质瘤是中枢神经系统中最具侵袭性和致命性的恶性肿瘤之一，起源于脑或脊髓中的胶质细胞。（剩余13692字）