育龄期女性垂体催乳素腺瘤手术疗效及预后预测模型研究

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关键词】育龄期女性；垂体催乳素腺瘤；经蝶手术；生化缓解；列线图 【中图分类号】 R651.1+3 【文献标志码】 A 【文章编号】1672-7770（2025）03-0291-07

Abstract：ObjectiveTo study the influencing factors of biochemical remission after neuroendoscopic transsphenoidal resection of prolactin adenoma in female patientsof reproductive age and to construct a relevant prediction model. MethodsThe clinical data of 232 patients underwent transsphenoidal prolactin adenoma resection in the Department of Neurosurgery，the Affiliated Hospital of Xuzhou Medical University from January 2O15 to May 2O23 were retrospectively analyzed，and they were randomly divided into a training group and a validation group according to the ratio of 7：3. Independent risk factors affecting biochemical remission after surgery were screened using unifactorial and multifactorial analyses and included in the prediction model. ResultsThe patients’ body mass index（BMI），preoperative Knosp classification of pituitary tumors， postoperative prolactinvalue on the first day，and Ki-67 were the independent risk factorsaffecting the patients' postoperative biochemical remisson. The area under the ROC curve of the prediction model built in this way was O.85 and O.94 in the training and validation sets，respectively，and was wellcalibrated and clinically useful. ConclusionsIn this study，a prediction model affecting biochemical remission after neuroendoscopic transsphenoidal prolactin adenoma resection was constructed by multifactorial analysis，which has good clinical utility and can provide clinical reference value for the selection of treatment options for female prolactin adenoma patients in reproductive age.

Key words：female of childbearingage；prolactinadenoma；transepithelial surgery; biochemical remission ； columnar line drawing

垂体腺瘤（pituitaryadenoma，PA）是临床常见的颅内原发性肿瘤，其在颅内肿瘤的发病率约为15% ，仅次于神经上皮源性肿瘤和脑膜瘤[1]。（剩余10795字）