原发性Meige综合征不同靶点脑深部电刺激疗效比较

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【中图分类号】 R651 【文献标志码】 A 【文章编号】 1672-7770（2025）03-0263-09

Abstract： ObjectiveTo compare the eficacy deep brain stimulation（DBS） with different targets in primary Meige syndrome（PMS）.MethodsThe clinical data 15 patients with PMS underwent DBS treatment targeting diferent sites in the University fromApril 2021 to June 2024 were analyzed retrospectively. The 15 patients with PMS received bilateral subthalamic nucleus（STN） or globus pallidus internus（GPi） DBS surgery. The Burke-Fahn-Marsden Dystonia Rating Scale（BFMDRS） （including motor and disability subscale），Hamilton Anxiety Scale（HAMA），and Hamilton Depression Scale（HAMD）were uniformly used to evaluate and record the preoperative and postoperative muscle tone，limb motor function，and mental status the enrolled patients，as well as to document the related postoperative complications.ResultsThe average improvement rate BFMDRS was 59.23% in15 patients at 3 months after surgery，and 67.87% in 10 patients at 12 months after surgery， respectively. The average improvement rates motor scores between patients who received GPi stimulation and STN stimulation were 65.80% and 71.70% ，respectively，and the stimulation the two targets could effctively improve the symptoms，but without statistical difference（ P>0.05 ）.The scores HAMA scale and HAMD scale were improved to different extent compared with those before operation，and the improvement rate HAMA scale in the STN group was better than that in the GPi group with statistical significance（ P<0.05 ）． Conclusions Both DBS targets are safe and eective in improving motor symptoms in patients with Meige syndrome，and there is no significant diffrence between two DBS targets for symptom improvement， and STN-DBS and anxiety symptoms improved better than GPi-DBS.

Key words： Meige syndrome; globus pallidus internus； subthalamic nucleus； deep brainstimulation；anxiety；depression

原发性 Meige 综合征（primary Meige syndrome，PMS）是一种成人发病的节段性肌张力障碍，其特征为不同程度的眼睑痉挛和口面颈肌张力障碍，可伴有下面部肌肉、口、舌、咽和颈部肌肉的复杂运动，包括双眼眼睑痉挛（blepharospasm，BSP）和口下颌肌张力障碍（oromandibular dystonia，OMD）[1]。（剩余13230字）