过量服用华法林致皮下血肿合并横纹肌溶解1例

打开文本图片集

【关键词】华法林；皮下血肿；横纹肌溶解；用药错误【中图分类号】 【文献标识码】A

【Abstract】This case involves a 53-year-old female patient who underwent mechanical mitral valve replacement and has been on long-term warfarin anticoagulant therapy， subsequently developed diffuse ecchymoses of the limbs and progressive both lower extremities swelling after she self-adjusted her warfarin dosage from 3mg to 6 mg daily over 5 consecutive days. After admission， the patient's international normalized ratio was 12.71，and creatine kinase level was 1，989.47U.L-1 0 which led to the diagnosis of coagulopathy and rhabdomyolysis due to warfarin overdose.Following discontinuation of warfarin and initiation of fluid resuscitation therapy， the patient's creatine kinase levels returned to normal after 6 d. This case underscores the necessity of refining long-term warfarin management strategies and enhancing patient education to improve medication adherence and ensure both the efficacy and safety of anticoagulation therapy.

【Keywords】Warfarin; Subcutaneous hematoma; Rhabdomyolysis; Medication errors

华法林是临床上用于治疗心脏瓣膜置换术、肺栓塞、静脉血栓等疾病的常用抗凝药物，可降低栓塞事件的发生风险。（剩余10958字）