基于隐结构结合关联规则探讨《太平惠民和剂局方》治疗疫病的方药规律

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【中图分类号】R289 【文献标识码】A

【Abstract】Objective To explore the regularity of prescriptions for epidemic disease in Taiping Huimin Heji Ju Fang based on the latent structure model and association rules analysis，and to provide references for modernepidemic treatment. Methods Prescriptions for epidemic diseases were extracted from Taiping Huimin Heji Ju Fang. A high-frequency herb matrix （frequency ≥10 ）was constructed，and high-frequency herbs were analyzed using Microsoft Excel 2016，Lantern 5.0，and IBM SPSs Modeler 18.0 for effcacy clasification， property/flavor/channel tropism statistics，latent structure modeling，and association rule analysis. Results Among the 200 collected herbal prescriptions，46 high-frequency medicinal materials were identified，such as licorice，fresh ginger，dried ginger，poriae，and ginseng. The top 3 drugs efcacy were tonifying deficiency， relieving surface and warming inner. The medicinal properties were mainly warm，and the medicinal flavors were pungent， biter，and sweet. The meridian tropisms mainly included the spleen meridian，lung meridian and stomach meridian.The analysis of latent structure model suggested that there were 8 types of common symptoms of epidemic disease，such as wind evil attack exterior， wind-cold-dampnes， wind-heat，excess-heat in tripleenergizer，dampness inhibitsqistagnation，yang deficiency，blockageandspleen-qideficiency.Theanalysis of association rules obtained licorice-ephedra and licorice-atractylodes，which with a core of licorice medicine， and the 16 association rules such as dried ginger-cinnamon，pericarpium citri reticulatae-mangnolia offcinalis and poriae-ginseng-atractylodes macrocephala after eliminating ginger， jujube and licorice. Conclusion Most of the medicines used in the treatment of epidemic diseases in Taiping Huimin Heji Ju Fang are pungent， biter and dispelling evil，the treatment should follow the principle of dispelling evil， warming yang to dissipate cold， dispelling dampness，clearing heat and expelling fire， inducing resuscitation，supporting the right and supplementing deficiency， which embodies the treatment principle of dispeling evil and supporting right，and provides reference and ideas for the treatment of clinical diseases based on syndrome differentiation.

【KeyWords】Epidemic disease; Taiping Huimin Heji Ju Fang; Data mining; Medication rules; Latent structure; Association rule

疫病是由疫病邪气引起的一类具有强烈传染性和流行性的外感疾病，相当于现代医学的传染病[1-2]，包括呼吸道和消化道传染病等。（剩余18601字）