基于数据挖掘与网络药理学分析马钱子不良反应特点与神经毒性机制研究

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[关键词］马钱子；不良反应；神经毒性；网络药理学；数据挖掘

[中图分类号］R285 [文献标志码］A [文章编号]0256-7415（2025）19-0158-07

DOI：10.13457/j.cnki.jncm.2025.19.028

Study on Adverse Reaction Characteristics and Neurotoxicity Mechanism of Strychni Semen Based on Data Mining and Network Pharmacology

YU Xinwei， TENG Xiaochun，WU Shanyong Department of Pharmacy，The Second Hospitalof Jiaxing，Jiaxing Zhejiang 314Ooo，China

Abstract：Objective：To analyze the characteristics of adverse reactions induced by Strychni Semen and explore thepotential mechanisms of its neurotoxicityusing data mining and network pharmacology.Methods：Literature reporting adverse reactions related to Strychni Semen was systematically retrieved from CNKI and VIP databases from their inception to November13，2024.A totalof97articles covering 325 patientcases were included.Through network pharmacology，agene-target network of toxic components was constructed，and molecular docking simulations were performed to identify potential mechanisms.Results：Adverse reaction cases were reported across 26 provinces / autonomousregions/municipalities in China，predominantlyafecting middle-agedand elderlypopulations.Multisysteminvolvement wasobserved，with neurological damage being the mostsevere manifestation （including fatal outcomes）.Overdosing and acidental ingestion were identifiedas primary causes.Network pharmacologyrevealed that toxiccomponents of Strychni Semen may induce neurotoxicity byregulating key protein families—muscarinic receptors （CHRM）and glycine receptors （GLRA）—thereby affcting signaling pathways including neuroactive ligand-receptor interaction，cholinergic synapse，and neurodegenerative pathways.Conclusion：The neurotoxic adverse reactions of Strychni Semen are associated with critical gene targets regulated by its toxic components.

Keywords：Strychni Semen；Adverse reactions；Neurotoxicity；Network pharmacology；Data mining

马钱子别名番木鳖，为马钱科植物马钱的成熟种子，入肝、脾经。（剩余7525字）