基于数据挖掘分析治疗慢性肾脏病5期（非透析）用药规律

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[中图分类号]R249；R277.5 [文献标志码］A [文章编号]0256-7415（2025）19-0013-05

DOl：10.13457/j.cnki.jncm.2025.19.003

Analysis of Medication Rules of CHEN Hongyu in Treating Stage 5 Chronic Kidney Disease（Non-Dialysis） Based on Data Mining

ZHU Fenggui，ZENG Jiali，CHEN Hongyu Hangzhou TCM Hospital of Zhejiang Chinese Medical University，Hangzhou Zhejiang 31Oo07，China

Abstract：Objective：To summarize the medication rules of Professor CHEN Hongyu in treating stage 5 chronic kidney disease（non-dialysis）using data mining techniques.Methods：Clinical case records of stage 5 CKD（nondialysis）patients treated byProfesorCHEN Hongyuat Hangzhou Hospital of Traditional Chinese Medicine were collected.Excel and SPSS software were employed to analyze herb application frequency，properties，flavors，and meridian tropism，aswell as to perform association rules analysis and cluster analysis.Results：A total of 410prescriptions were analyzed，comprising 5O herbswith a cumulative application frequencyof 5 689.Highfrequency herbs included Curcumae Rhizoma，Spargani Rhizoma，Persicae Semen，Chuanxiong Rhizoma，Angelicae Sinensis Radix，Salviae MiltiorrhizaeRadix etRhizoma，and Pheretima，etc.Herb properties were predominantly neutral，warm，and cold；flavors were mainly sweet，biter，and pungent；primary meridian tropisms were the liver， splen，and kidney.Herbal eficacies ranked in descending order of occurrence was as follows：blood-activating and stasis-resolving herbs，deficiency-tonifying herbs，heat-clearing herbs，liver-calming and wind-suppressing herbs. Associationruleanalysis identified26core herb pairs，whilecluster analysis yielded2categoriesof herb formulations. Conclusion：Profesor CHEN's treatment for stage 5 CKD（non-dialysis） emphasizes the application of neutral and warm herbs in properties，targeting the liver，spleen，and kidney meridians in meridian tropism.The core strategy focuses on blood-activating and stasis-resolving，supplemented by deficiency-tonifying，deficiency-heat-clearing， and liver-calming and wind-suppressing herbs，with modifications using astringents，purgatives，and wind-dampexpelling herbs as clinically indicated.

Keywords：Stage 5 chronic kidney disease；Data mining；Medication rules；Experience of famous physician; CHEN Hongyu

慢性肾脏病5期处于慢性肾病的终末期1]，其主要标准为肾脏结构异常及（或）功能障碍 ⩾3 个月，肾小球滤过率 <15mL/（min⋅1.73m2）12 ，多有水肿、面色黧黑、恶心呕吐、食欲减退、皮肤瘙痒、口中尿臭味等临床表现，很大程度上影响患者生活质量，且致死率较高[3-4]。（剩余4986字）