杨树桑黄菌次生代谢产物及其生物活性研究

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Study on secondary metabolites and their biological activities Sanghuangporus vanini

Liu Xuwen，ZhouJie，Ye Dongyan，Li Qianhui，YinShuren，Xu Ziwen，Liu Dan，NurbiyamNurmamat，andBai Helong （College ， ， 130032）

Abstract Objective To study the chemical composition and biological activity solid culture Sanghuangporus vaninii.MethodsThe compounds were isolated and purified by ultrasonic extraction and semipreparative liquid chromatography.Their structures were identified by NMR data，and their inhibitory activities against a -amylase and a -glucosidase were evaluated. ResultsSeven compounds were isolated from the extract Sanghuangporus vaniniiand identified as hispidin （1），scopoletin （2），phellifuropyranone A （3）， penilactone D （4），（ 3E. 6S）-3-heptene-1，6-diol （5），ethylorselinate （6），4-（2-hydroxyethyl）benzene-1，2-diol （7）. The inibitory activity a -amylaseand a -glucosidase showed that compound2 had strong inhibitory activity against a -amylase and （204号 a glucosidase.The inhibition rates compound 2 on the two enzymes were 82% and 68% ， respectively， and the IC50 was 29.28μmol/L and 61.28μmol/L ， respectively. It showed mixed inhibition a -amylase and competitive inhibition a -glucosidase.ConclusionThis study enriched the chemical composition and biological activity the solid culture Sanghuangporus vanini， and provided a basis for its further development and application.

Key wordsSanghuangporus vanini; a -amylase; a -glucosidase; Inhibition type

桑黄是一种珍贵的多年生药用真菌[1]，据记载，桑黄又名桑耳、桑臣和桑黄菇等[，有“森林黄金”之美称[3]，主要生长在桑树、柳树和桦树等阔叶树的树干或树桩上[4]。（剩余11528字）