近40年真菌代谢产物中环状四肽、五肽和六肽研究进展

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中图分类号：R9 文献标志码：A

Review of cyclic tetra-， penta-， and hexa-peptides from the metabolite profile of fungi in the last four decades

Jiang Yuel2，Wang Yu1，2 ，Yi Xiangxi¹， Gao Chenghai1，2，Liu Yonghong1，2，Cao Pei12，and Bai Meng1.2 （1 Guangxi KeyLaboratoryofMarine Drugs，Guangxi Universityof Chinese Medicine，Nanning530200; 2 Institute ofMarine Drugs， Guangxi University of Chinese Medicine，Nanning 530200）

AbstractCyclopeptides are a kind of non-linear nitrogen-containing compounds mainly formed by amino acid residues through peptidebonds.Gramicidin as an antibacterial agent is the first memberof this family found in the 1940s.Since then，more natural cyclopeptide analogues have been exponentiallyreportedover the subsequent decades. This article providedacomprehensive overview of the origins，chemical structural features，and biological activities of 121cyclic tetra-，penta-，and hexa-peptides obtained from various fungalresourcesbetween December 1986 and June 2024.Inaddition，aconsiderable numberof derivatives had exhibited diversified pharmacologicalactivities relating to antineoplastic，ntibacterial，antimalarial，anti-flammatoryandantivialaspcts，whichmightispirevuableideas for the development of new drugs.This review provided reference data for exploring and discovering cyclic tetra-， penta-，and hexa-peptides with biological activities in the future.

Key wordsFungi; Secondary metabolites; Cyclic tetra-， penta-， and hexa-peptides; Chemical structures; Biological activity

真菌是自然界中仅次于昆虫的第二大生物类群]。（剩余22594字）