磁共振非对称回波最小二乘估算法迭代水脂分离序列技术在评估2型糖尿病患者肝脏脂肪沉积中的应用与价值研究
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【Abstract】ObjectiveTo investigateandanalyze the correlation between the quantification of liver fat deposition byiterativedecompositionof waterandfatwithecho asymmetricaland least-squares estimationquantitation sequence （IDEAL-IQ）technique and type 2 diabetes melitus （TDM）.MethodsA total of 40 patients with TDM （TDM group）andvoluntees withnormal blood glucose （NGT group）who underwent clinical laboratory examination in Hospital Afiliated to from October2O23 to September 2024 were retrospectively selected as the studysubjects.Allpatientsunderwent MRI IDEAL-IQ examination，and relevant clinical indicators wererecorded andcorrelationanalysis wasperformed.ResultsThefatfractionoftheleftliver，thefatfractionoftheright liverand theaverage fatfractionof thewhole liver in the TDMgroup were higher thanthose in theNGT group，and the differences were statistically significant（ P <0.05）.The levels of triglyceride， fasting blood glucose and glycated hemoglobin in the TDM group were higher than those in the NGT group，andthe levels of high-density lipoprotein cholesterol were lower than those in the NGT group， with statistical significance（all P <0.05）.Spearman rank corelation analysisshowed thatInTDM patients，thedegreeof liverfat deposition（representedbythe whole liver average fat fraction）was positivelycorrelated withthe levelsoffasting blood glucose （r=O.993，PO.O01），triglycerde （r=0.594， P <0.001） and glycated hemoglobin （r=O.523， P <0.001）.Conclusion The increase of liver fat fraction quantified bythe IDEAL-IQ technique iscommon in type2 diabetes patients，and the degree offat deposition is closelyrelatedtothe levelsoffasting bloodglucose，triglycerideandglycated hemoglobin.This finding notonly revealstheeffctiveness ofIDEAL-IQinquantifying fattdeposits inthe liverbutalsosuggestsitspotential clinical application in predicting type 2 diabetes risk and monitoring disease progression.
【Key Words】Diabetes melitus，type 2；Least-squaresanalgsis；Fatty liver; Quantitative evaluation；Corr elationanalysis
作为全球广泛流行的代谢性疾病之一，2型糖尿病发病机制复杂[1]。（剩余6939字）
