TRAP1在促进血管平滑肌细胞衰老和动脉粥样硬化中的研究进展

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【Abstract】Vascularsmohmusclecell senescenceisssntialfortheinitiationandprogressinofatherosclerosis.umornosis factorreceptorasoadprote（TAP）ispoatoodrialproteininteatsokprot9Omilydisatedwi celularsenescence.heepigeneticregulationandmetabolicreprogrammingofTRAPlpromotevascularsmothusclecellsescence， therebyacceleratingtheprocessofatheroslerosis.ThisarticleeviesteolesofAPonvscularsmthmusclecellsnesceand atherosclerosis，aiming to provide new ideas for targeted therapy of atherosclerosis.

【Keywords】Tumor necrosis factorreceptor-assciatedprotein1;Vascularsmoothmuscle;Cellsenescence;Atherosclerosis

动脉粥样硬化（atherosclerosis，AS）是一种慢性炎症性疾病，其病理生理过程涉及血管内皮损伤、脂质沉积、平滑肌细胞增殖和迁移，以及炎症反应等多个环节[1]。（剩余14316字）