HADHA的乙酰化修饰在心血管疾病中的作用研究进展

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【关键词】羟酰辅酶A脱氢酶三功能多酶复合物亚基 α ；乙酰化修饰；心肌能量代谢；炎症小体；心血管疾病 【DOI]10.16806/j. cnki.issn.1004-3934.2025.10.010

【Abstract】Cardiovasculardseasesareamongtheleadingcausesofglobalmorbidityandmortaityithitspathogenesiscloselylinked toabnoralmyocardialnergymetabolismandinflammatoyresponsesHyroxycyl-CAdehdrogenasetrifunctioalmultienzeoplex subunit α （HADHA），a key enzyme in fatty acid β -oxidation，plays a critical role in maintaining myocardial energy homeostasis.Recent studieshaverevealedthatHADHAacetyltionmodulatesmyocardialenergymetabolismandinflammatoryresponsesbyregulatingits enzmaticatitdabilitkinittspiadoasleaotablystoacyse3ilentifoati relatedenze3ndgneralontrolonderepresible-likeproteininfuencefattyacidoidationandinflammatoryresposesby modultingtheacetylationstatusofHADHA.Therefore，targeting HADHAacetylationmayemergeasanoveltherapeuticstrategyfor cardiovasculardiseases.ThisreviewsummarizesthelatestreseachprogressandelucidatesthemechanismsbyhichHADHAacetylation contributes to cardiovascular diseases.

【Keywords】 Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit α ; Acetylation modification; Myocardial energ. metabolism;Inflammasome;Cardiovascular disease

心血管疾病（cardiovasculardisease，CVD）是全球范围内导致人类死亡和残疾的主要疾病类型之一，其发病率和死亡率长期居于各类疾病谱的前列，已成为威胁公共健康的重大医学问题[1]。（剩余13597字）