IV型心肾综合征发病机制研究进展

【Abstract】 Type IV cardiorenal syndrome （CRS）has a high prevalence and poor prognosis，and how to efectively prevent and treat it hasbenamajorhallngeintemdicalfield.Thepathogensisivovesuulatioofureictoxisultinginintestinalfadisis leading tofurtheraccumulationofindoxylsulfate，trimethylamine-Noxide，andreductionofshort-chainfatyacid，hemodyamicand neurohumoralibalane，hroicidneydisease-mineralandbonedisoder，ndaeiaofhoicnaldisease.Thedevelopntofuic cardiomyopathyfurtherexacerbatescardiovascularijuryndtediscoveryoftepathogenicmechanismofmicroRAgeneticgulationhas provided a new vision for the study of the pathogenesis of type IV CRS.This review summarizes the latest research progress on the pathogenesis of typeVCRS，imingtoprovidenewstrategiesandotionfordiseasepreventionandtreatmentbyevealingpotentialherapeutictagets.

【Keywords】Cardiorenalsyndrome;Uremictoxis;Chonickidneydisease-mineralandbonedisorder;Anemiaofchroncrenaldisease; MicroRNA

基于急性透析质量倡议]对心肾综合征（cardiorenalsyndrome，CRS）的定义和分型，I型CRS主要指慢性肾脏病（chronic kidneydisease，CKD）引发的心血管损伤，即慢性CRS。（剩余12811字）