白血病患儿癌症相关认知障碍前哨因子及其评估工具研究进展

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【中图分类号】R47

【文献标志码】A【收稿日期】2024-10-04

Research advances in sentinel factors for cancer-related cognitive impairment and related assessment tools in children with leukemia

ZengYan'，Mo Lin²，Chen Zefang'，Liu Tao' （1.Chongqing Medical University School of Nursing/Departmentof Nursing，Children's Hospital of Chongqing Medical University;2.National Clinical Research Center for Child Health andDisorders/Ministryof Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders/Outpatient Department， Children's Hospital of Chongqing Medical University） 【Abstract】Cancer-relatedcognitiveimpaimentisacommonandseriouscomplicationinchildren withleukemia，whichaffects the qualityflongtermurvialandasdverseimpactoeirsholing，ife，ndocializatio.Toughaliteraturereviethistice summarizestelctofocaedieptinsoaietyepresgo ateexposure，decreasedlysophosphatidylholinelevelsandelevatedspingomyelinoncentratiosinerebrospialfuid，198 genotype，and increases in inflammatory factors（TNF- α ，IL-6，and IL-8）.The existing assessment tools for sentinel factors lack sensitivityandspeciicityndubsequentlargsampleuicentersdiessouldbeonductedtoalidateteccuracyofteboeidicatorsnpredictingcaner-relatedcognitiveimpairmentinchildrenwithlukemia，soastoachieveearlyinterventionandiprovethe quality of long-term survival.

【Keywords】leukemia;cognitive impairment;cancer;children

癌症是全世界儿童死亡的主要原因，已成为国家重大公共卫生问题[2-3]。（剩余16197字）