基于临床表现和病理学特征的阿尔茨海默病临床亚型研究进展

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【中图分类号】R741【文献标志码】A【收稿日期】2024-11-30

Research advances in clinical subtypes of Alzheimer's disease based on clinical manifestations and pathological features

Zhou Juan ，Zeng Deyang²，Liu Xiaochang²，Zeng Yan²，Huang Zhaolan³，Yang Xue4，Wang Xing，Tan Wei （1.School of Public Health，Wuhan University of Science and Technology;2. Brain Science and Advanced Technology Institute， Wuhan University of Science and Technology;3. Department of Gastroenterology ， Geriatric Hospital Affiliated to Wuhan University of Science and Technology;4. Department of Neurosurgery， Geriatric Hospital Afiliated to Wuhan University of Science and Technology ;5. Department of Neurology，Geriatric Hospital Afliated to Wuhan Universityof Science and Technology;6. Department of Medical Imaging ， GeriatricHospitalAffiliatedtoWuhanUniversityofScienceand Technology）

【AbstractAlzheimer’sdisease（AD）isaneurodegenerativediseasewithhighlyheterogeneouspathologicalandclinicalmanifestations，anditisotomoncusefmtia.iserogeniyossalgesforagnosis，eament，ndvaatingoel pharmacological eficacy.Thisreviewsummarizes thelatestprogressinthemajorclinicalsubtypesofADbasedonclinicalmanifestations，genetic，andpathologicalfeatures.Earlyonsetandlate-onsetADclinicalsubtypesmaysharethesamesymptomsbutiferin etiology，ageetdefesersiatedoicaldal cantly inclinicalmanifestations，athologicalfatures，nddagnosticiteria.ResearchonADsubtypesbasedonimagingandoics datahasalsomadeconsiderableproges.ThisreviealsooutliesthemoleularpathologicalheterogeneityofAD.Adeepunderstandingofthesehterogeiisisucialfoiagois，toulatioofpaclogicalratentsategisndlicalt.

【Key words】Alzheimer's disease;heterogeneity ;clinical subtype;molecular pathology;molecular imaging

阿尔茨海默病（Alzheimer'sdisease，AD）是一种病理和临床表现异质性很强的神经退行性疾病。（剩余17976字）